HIGH FAT DIET INCREASES THE SEVERITY OF COLLAGEN-INDUCED ARTHRITIS IN MICE BY ALTERING THE GUT MICROBIAL COMMUNITY

High fat diet increases the severity of collagen-induced arthritis in mice by altering the gut microbial community

Abstract Objectives Research has demonstrated that obesity may be associated with rheumatoid arthritis (RA).In addition, gut microbiota and its metabolites contribute to the occurrence and development of RA and obesity.However, the mechanism by which obesity affects RA remains unclear.In this study, we aimed to investigate whether gut microbiota an

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Notes from the Field: The Humanitarian Crisis in Ukraine

Humanitarian crises are politically and socially charged, and as actors, donors and organizations move in to help, duplication of services can ensue.Despite the influx of humanitarian Past Cargo actors into the war zone of eastern Ukraine, more are still needed to address immediate threat to the health of more than 5 million at-risk people in the a

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Estrogen, through estrogen receptor 1, regulates histone modifications and chromatin remodeling during spermatogenesis in adult rats

Estrogen receptors (ESR1 and ESR2) play crucial roles in various processes during spermatogenesis.To elucidate individual roles of ESRs in male fertility, we developed in vivo selective ESR agonist administration models.Adult male rats treated with ESR1 and ESR2 agonist for 60 days show spermatogenic defects leading to reduced sperm counts and fert

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